Ning Chen
نویسندگان
چکیده
Synaptic transmission involves protein-protein interactions underlying presynaptic transmitter release and postsynaptic signal reception and propagation. Recently, interaction proteomics technology enabled us to elucidate the constituents of synaptic protein complexes, and to detect both known and novel interactors without bias. The pre-synaptic protein network dynamically regulates synaptic vesicle trafficking, fusion and replenishment. In this study we performed large-scale immunoprecipitation followed by mass spectrometry identification to characterize the pre-synaptic protein interactome. Our analysis confirmed most previously reported protein-protein interactions, and detected novel interacting proteins and new functional groups. Based on these data, a preliminary protein network model of synaptic vesicle recycling is proposed. Chapter 3. Interaction proteomics analysis of the pre-synapse 33
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